CLP257

Overview

CLP257 is a selective K + -Cl cotransporter KCC2 activator with an EC 50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-110143
• CAS No.: 1181081-71-9
• Molecular Formula: C14H14FN3O2S
• Molecular Weight: 307.34
• Purity: 99.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 1.79 mg/mL (5.82 mM); Clear solution
• Availability: In-stock

Source

Original product source