PDI-IN-1

Overview

PDI-IN-1 is a cell-permeable PDI covalent inhibitor with an IC 50 of 1.7 μM against bovine PDI . PDI-IN-1 specifically modifies the Cys397 residue at the active site of human PDI , selectively labels endogenous PDI in living mammalian cancer cells, and effectively inhibits PDI-mediated insulin aggregation in vitro. PDI-IN-1 exhibits significant anti-tumor activity and inhibits the growth of various cancer cell lines.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PDI

Product Information

• Catalog No.: HY-110172
• CAS No.: 1461648-55-4
• Molecular Formula: C30H37N3O7S
• Molecular Weight: 583.70
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (8.57 mM); Clear solution
• Availability: In-stock

Source

Original product source