VU0422288

Overview

VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs . VU0422288 inhibits mGluRs with EC 50 s of 125 nM, 146 nM, and 108 nM for mGluR4 , mGluR7 , and mGluR8 , respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR

Product Information

• Catalog No.: HY-110190
• CAS No.: 1630936-95-6
• Molecular Formula: C17H11Cl2N3O2
• Molecular Weight: 360.19
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution
• Availability: In-stock

Source

Original product source