(R,S,R)-ML334

Overview

(R,S,R)-ML334 is the isomer of ML334 ( HY-110258 ), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-110258B
• CAS No.: 1432065-33-2
• Molecular Formula: C26H26N2O5
• Molecular Weight: 446.50
• Purity: 98.57%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (11.20 mM); Clear solution
• Availability: In-stock

Source

Original product source