A-425619

Overview

A-425619 is an orally active and selective transient receptor potential type V1 ( TRPV1 ) antagonist. A-425619 blocks Capsaicin ( HY-10448 )- and N-arachidonoyl-dopamine (NADA)-induced Ca 2+ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury.

Application

Products | Products > Disease Areas > Pain | Products > Disease Areas > Hypertension | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TRP Channel | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-110292
• CAS No.: 581809-67-8
• Molecular Formula: C18H14F3N3O
• Molecular Weight: 345.32
• Purity: 99.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source