GR148672X

Overview

GR148672X is an inhibitor of carboxylesterase 1 ( CES1 ) and hepatic microsomal triglyceride hydrolase ( TGH ). GR148672X blocks the catalytic activity of CES1 , impairs the functions of triglyceride and cholesteryl ester lipase , reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis . GR148672X can be used in studies related to colorectal cancer and atherosclerosis.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Atherosclerosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Carboxylesterase (CES) | Products > Signaling Pathways > Free Fatty Acid Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-110390
• CAS No.: 263890-70-6
• Molecular Formula: C15H11F3N2O2S
• Molecular Weight: 340.32
• Purity: 99.58%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution
• Availability: In-stock

Source

Original product source