GR148672X

CAS No.：263890-70-6
Grade：99.58%
Formula：C15H11F3N2O2S
M.W.：340.32
Solvent：≥ 2.08 mg/mL (6.11 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

GR148672X is an inhibitor of carboxylesterase 1 ( CES1 ) and hepatic microsomal triglyceride hydrolase ( TGH ). GR148672X blocks the catalytic activity of CES1 , impairs the functions of triglyceride and cholesteryl ester lipase , reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis . GR148672X can be used in studies related to colorectal cancer and atherosclerosis.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Atherosclerosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Carboxylesterase (CES) | Products > Signaling Pathways > Free Fatty Acid Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

Catalog No.: HY-110390
CAS No.: 263890-70-6
Molecular Formula: C15H11F3N2O2S
Molecular Weight: 340.32
Purity: 99.58%
Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution
Availability: In-stock

Source

Original product source

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