KP-457

Overview

KP-457 is a selective a disintegrin and metalloproteinase 17 ( ADAM17 ) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10 , and IC 50 s are 11.1 nM ( ADAM17 ), 748 nM ( ADAM10 ), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

Application

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Product Information

• Catalog No.: HY-110397
• CAS No.: 1365803-52-6
• Molecular Formula: C21H24N2O7S2
• Molecular Weight: 480.55
• Purity: 98.88%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution
• Availability: In-stock

Source

Original product source