NPS 2390 is an allosteric antagonist of calcium-sensing receptor ( CaSR ) and mGluR1/5 . NPS 2390 inhibits the PI3K / Akt / mTOR signaling pathway, reduces hypoxia-induced intracellular calcium elevation, decreases the expression of autophagy ( autophagy ) proteins, regulates the expression of phenotypic marker proteins, and inhibits the proliferation of pulmonary artery smooth muscle cells. NPS 2390 attenuates the endogenous apoptosis ( apoptosis ) pathway, increases the expression level of Bcl-2 , downregulates the expression levels of Bax , cytochrome c and caspase-3 , alleviates cerebral edema and improves neurological function in rat models. NPS 2390 can be used in studies related to hypoxic pulmonary hypertension, traumatic brain injury, stroke and pain.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Pain | Products > Disease Areas > Traumatic Brain Injury | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > mGluR | Products > Signaling Pathways > CaSR | Products > Signaling Pathways > PI3K
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