(S)-LY-3381916

Overview

(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC 50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 ( IDO1 ) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO)

Product Information

• Catalog No.: HY-111540B
• CAS No.: 2166616-76-6
• Molecular Formula: C23H25FN2O3
• Molecular Weight: 396.45
• Purity: 99.06%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 7.5 mg/mL (18.92 mM); Clear solution
• Availability: In-stock

Source

Original product source