BI-749327

Overview

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC 50 s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Pain | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-111925
• CAS No.: 2361241-23-6
• Molecular Formula: C23H21F3N4O2
• Molecular Weight: 442.43
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.70 mM); Clear solution
• Availability: In-stock

Source

Original product source