TP0463518

Overview

TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3 . TP0463518 competitively inhibits human PHD1 ( IC 50 =18 nM), PHD2 (K i =5.3 nM), and PHD3 ( IC 50 =63 nM), and targets monkey PHD2 with an IC 50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia.

Application

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Product Information

• Catalog No.: HY-112144
• CAS No.: 1558021-37-6
• Molecular Formula: C20H18ClN3O6
• Molecular Weight: 431.83
• Purity: 99.25%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution
• Availability: In-stock

Source

Original product source