VRT-043198

Overview

VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits K i values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Drug Metabolite

Product Information

• Catalog No.: HY-112226
• CAS No.: 244133-31-1
• Molecular Formula: C22H29ClN4O6
• Molecular Weight: 480.94
• Purity: 97.66%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 4.5 mg/mL (9.36 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source