EXEL-0346 is an orally active glucosylceramide synthase ( GCS ) inhibitor, with an IC 50 of 2 nM. EXEL-0346 combined with insulin increases pAkt . EXEL-0346 effectively reduces the levels of Glucosylceramide, Lactosylceramide and GM3. EXEL-0346 improves obesity and diabetes.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Glucosylceramide Synthase (GCS)
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