F-1

Overview

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC 50 s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALK WT , ROS1 WT , ALK L1196M and ALK G1202R , respectively.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK) | Products > Signaling Pathways > ROS Kinase

Product Information

• Catalog No.: HY-112801
• CAS No.: 2244775-31-1
• Molecular Formula: C22H27ClN8O3S
• Molecular Weight: 519.02
• Purity: 98.03%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (4.01 mM); Clear solution
• Availability: In-stock

Source

Original product source