GSK2646264

Overview

GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase ( SYK ) inhibitor with a pIC 50 of 7.1. GSK2646264 also inhibits other kinases with pIC 50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK , LRRK2 , GSK3β , JAK2 , VEGFR2 , Aurora B and Aurora A , respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Obesity | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Src | Products > Signaling Pathways > LRRK2 | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > JAK | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > Syk

Product Information

• Catalog No.: HY-112809
• CAS No.: 1398695-47-0
• Molecular Formula: C24H26N2O2
• Molecular Weight: 374.48
• Purity: 99.74%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.25 mg/mL (3.34 mM); Clear solution
• Availability: In-stock

Source

Original product source