N2,N2-Dimethylguanosine

Overview

N2,N2-Dimethylguanosine is a methylated modified nucleoside present in RNA and serves as a structural modification component of tRNA. N2,N2-Dimethylguanosine inhibits reverse transcriptase-mediated cDNA synthesis and is one of the key modifications affecting sequencing efficiency in high-throughput RNA sequencing . N2,N2-Dimethylguanosine can be selectively demethylated at one methyl group by AlkB mutant enzymes (such as D135S/L118V) and converted to N2-methylguanosine, thereby reducing the inhibition of reverse transcription.

Application

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Product Information

• Catalog No.: HY-113137
• CAS No.: 2140-67-2
• Molecular Formula: C12H17N5O5
• Molecular Weight: 311.29
• Purity: 99.40%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.5 mg/mL (4.82 mM); Clear solution
• Availability: In-stock

Source

Original product source