Guanidinoethyl sulfonate

Overview

Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors ( GlyR ) ( IC 50 =565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABA A receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury.

Application

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Product Information

• Catalog No.: HY-113329
• CAS No.: 543-18-0
• Molecular Formula: C3H9N3O3S
• Molecular Weight: 167.19
• Purity: 99.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 25 mg/mL (149.53 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source