Prostaglandin J2

Overview

Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor ( DP ) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis . Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Prostaglandin Receptor | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-113366
• CAS No.: 60203-57-8
• Molecular Formula: C20H30O4
• Molecular Weight: 334.45
• Purity: 98.1%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source