Gamma-glutamylcysteine

Overview

Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK , SIRT1 , IL-4 / STAT6 , AC / cAMP / PI3K , IGF-1R / IRS1 / PI3K , and Nrf2 signaling pathways; it inhibits NF-κB , JAK1 / STAT1 / 3 , MAPKs , cadmium-induced p38 MAPK , JNK , and PI3K / Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4 , induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis ( Apoptosis ), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis ( Ferroptosis ), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Inflammatory Bowel Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > STAT | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > JAK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-113402
• CAS No.: 636-58-8
• Molecular Formula: C8H14N2O5S
• Molecular Weight: 250.27
• Purity: 98.53%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 100 mg/mL (399.57 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source