Dehydroepiandrosterone sulfate

Overview

Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABA A receptor and agonist activity of σ 1 receptor . Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABA A receptor-mediated chloride influx, enhance NMDA receptor activity through σ 1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality.

Application

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Product Information

• Catalog No.: HY-113416
• CAS No.: 651-48-9
• Molecular Formula: C19H28O5S
• Molecular Weight: 368.49
• Purity: 99.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.78 mM); Clear solution
• Availability: In-stock

Source

Original product source