15(R)-Lipoxin A4

Overview

15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2 . 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15 , as well as the pro-resolving receptor ALX . 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3 , Lyn , STAT-3 and STAT-6 . 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > STAT | Products > Signaling Pathways > COX | Products > Signaling Pathways > Lipoxygenase

Product Information

• Catalog No.: HY-113509B
• CAS No.: 171030-11-8
• Molecular Formula: C20H32O5
• Molecular Weight: 352.47
• Purity: 98.3%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source