RS-87337 is an orally active piperazine-amidine hybrid class Ia (inhibiting V max , IC 50 = 17 μM)/class III (prolonging ADP90, EC 15 = 2 μM) antiarrhythmic agent with selectivity for ventricular conduction . RS-87337 inhibits cardiac sodium channel , thereby reducing the maximum depolarization rate of action potential, with moderate onset and recovery kinetics. RS-87337 reduces cardiac outward potassium conductance ( I_K ), thus prolonging action potential duration. RS-87337 is applicable to research related to arrhythmia, ventricular arrhythmia, ventricular fibrillation, and myocardial ischemia-reperfusion injury.
Products | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Heart Disease | Products > Disease Areas > Ischemia-Reperfusion Injury | Products > Disease Areas > Arrhythmias | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Potassium Channel
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