(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase ( 15-LOX ) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ . (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.
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