LY 223592 (Compound I-a) is a Gemcitabine ( HY-17026 ) derivative. LY 223592 has the biological activity of highly selective inhibition of lung cancer cell proliferation ( IC 50 = 5.6 nM in A549 cells) and low cytotoxicity to normal cells. LY 223592 can be used for the research of cancer , such as non-small cell lung cancer (NSCLC).
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