UNC-2170

Overview

UNC-2170 is a functionally active, fragment-like ligand for 53BP1 ( IC 50 =29 µM; K d =22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-115531
• CAS No.: 1648707-58-7
• Molecular Formula: C14H21BrN2O
• Molecular Weight: 313.23
• Purity: 98.84%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution
• Availability: In-stock

Source

Original product source