ML077

Overview

ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 ( KCC2 ) with an IC 50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak ( IC 50 > 50 μM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > NKCC | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-115606
• CAS No.: 1135304-61-8
• Molecular Formula: C17H16N4OS2
• Molecular Weight: 356.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source