EPZ004777 formate

Overview

EPZ004777 formate is an effective and selective DOT1L inhibitor, with IC 50 being 0.4 nM. EPZ004777 formate reduces the levels of H3K79me2 and H3K79me1 , significantly down-regulating the expression of HOXA9 and MEIS1 . EPZ004777 formate selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis ( apoptosis ) of leukemia cells. EPZ004777 formate can be used for the study of leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-115619
• CAS No.: 1338466-77-5
• Molecular Formula: C29H43N7O6
• Molecular Weight: 585.70
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source