Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA A receptor . Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol ( HY-B0649 ). Cipepofol can activate the sirtuin1 ( Sirt1 )/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .
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