GSK256471

Overview

GSK256471 is a non-peptide tachykinin NK3 receptor antagonist with a pK i of 8.9 for the human recombinant NK3 receptor and 8.4 for the guinea pig native receptor. GSK256471 exhibits >100-fold selectivity for NK1 ( pK i = 5.2) and NK2 ( pK i = 7.3) receptors. GSK256471 noncompetitively inhibits neurokinin B (NKB) ( HY-P0242 )-induced inositol phosphate accumulation, and this inhibition is irreversible. GSK256471 inhibits wet dog shaking behavior and suppresses dopamine release. GSK256471 could be used to study schizophrenia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Neurokinin Receptor

Product Information

• Catalog No.: HY-116268
• CAS No.: 1133706-08-7
• Molecular Formula: C29H29N3O3S
• Molecular Weight: 499.62
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source