D-threo-PDMP

Overview

D-threo-PDMP is a potent glucoceramide synthase ( GCS ) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3 ) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP can be used to study diseases related to targeted glycosphingolipid metabolism.

Application

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Product Information

• Catalog No.: HY-116392E
• CAS No.: 109836-82-0
• Molecular Formula: C23H38N2O3
• Molecular Weight: 390.56
• Purity: 99.50%
• Storage: -20°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: ≥ 5 mg/mL (12.80 mM); Clear solution
• Availability: In-stock

Source

Original product source