D-threo-PDMP hydrochloride

Overview

D-threo-PDMP hydrochloride is a potent glucoceramide synthase ( GCS ) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3 ) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP hydrochloride inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP hydrochloride inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP hydrochloride can be used to study diseases related to targeted glycosphingolipid metabolism.

Application

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Product Information

• Catalog No.: HY-116392F
• CAS No.: 139889-62-6
• Molecular Formula: C23H39ClN2O3
• Molecular Weight: 427.02
• Purity: 98.0%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1.25 mg/mL (2.93 mM); Clear solution
• Availability: In-stock

Source

Original product source