L-744832

Overview

L-744832 is a farnesyl transferase inhibitor . L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras , but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis . L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Farnesyl Transferase | Products > Signaling Pathways > Ras | Products > Signaling Pathways > TGF-β Receptor

Product Information

• Catalog No.: HY-116428
• CAS No.: 160141-09-3
• Molecular Formula: C26H45N3O6S2
• Molecular Weight: 559.78
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source