L-744832

CAS No.：160141-09-3
Grade：99.98%
Formula：C26H45N3O6S2
M.W.：559.78

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

L-744832 is a farnesyl transferase inhibitor . L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras , but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis . L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Farnesyl Transferase | Products > Signaling Pathways > Ras | Products > Signaling Pathways > TGF-β Receptor

Product Information

Catalog No.: HY-116428
CAS No.: 160141-09-3
Molecular Formula: C26H45N3O6S2
Molecular Weight: 559.78
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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