SB-236057 is an inverse agonist of the 5-HT 1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1 . SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis.
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