CFMMC is a selective allosteric metabotropic glutamate receptor 1 ( mGluR1 ) antagonist. CFMMC inhibits L-glutamate-induced intracellular Ca 2+ mobilization ([Ca 2+ ]i) in Chinese hamster ovary cells expressing recombinant human mGluR1a with an IC 50 value of 50 nM. CFMMC is promising for research of various central nervous system disorders, such as schizophrenia, epilepsy, anxiety, pain, cognitive dysfunction and drug abuse.
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