BRD5648

Overview

BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC 50 of 66 nM and a K d of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC 50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML).

Application

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Product Information

• Catalog No.: HY-116830B
• CAS No.: 2056261-42-6
• Molecular Formula: C20H23N3O
• Molecular Weight: 321.42
• Purity: 99.08%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 7.5 mg/mL (23.33 mM); Clear solution
• Availability: In-stock

Source

Original product source