Sm4

Overview

Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding ( IC 50 = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction ( IC 50 = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ , DDX1 , DDX17 , ILF3 , SOX7 and STAT1 , modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Oct3/4 | Products > Signaling Pathways > Notch | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-116940
• CAS No.: 365542-77-4
• Molecular Formula: C19H16O3
• Molecular Weight: 292.33
• Purity: 99.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (4.28 mM); Clear solution
• Availability: In-stock

Source

Original product source