FR900359 is a depsipeptide selective inhibitor of Gα q/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin ( HY-W250978A )-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .
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