AVN-101

Overview

AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist ( K i of 153 pM), with slightly lesser potency toward 5-HT6 , 5-HT2A , and 5HT-2C receptors ( K i values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 also exhibits a rather high affinity toward histamine H1 ( K i of 0.58 nM) and adrenergic α2A , α2B , and α2C (K i = 0.41-3.6 nM) receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > Adrenergic Receptor

Product Information

• Catalog No.: HY-117046
• CAS No.: 1025725-91-0
• Molecular Formula: C21H24N2
• Molecular Weight: 304.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source