Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases ( DYRKs ) and CDC-like kinases ( CLKs ). Leucettine L41 can also inhibit GSK-3 singnaling. Leucettine L41 can inhibit cell apoptosis and ROS production. Leucettine L41 can promote β-cell cell cycle progression, cell proliferation and increase insulin secretion. Leucettine L41 can be used for the researches of neurological disease and metabolic disease , such as Alzheimer’s disease (AD) and diabetes.
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