FzM1.8

Overview

FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC 50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K .

Application

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Product Information

• Catalog No.: HY-117163
• CAS No.: 2204290-85-5
• Molecular Formula: C18H14N2O4
• Molecular Weight: 322.31
• Purity: 98.93%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (6.45 mM); Clear solution
• Availability: In-stock

Source

Original product source