LG190178 is a non-steroidal vitamin D receptor ( VDR ) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor ( RXR ), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis , making it useful for research in psoriasis, osteoporosis, and cancer .
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