KSC-34

Overview

KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PDI

Product Information

• Catalog No.: HY-117570
• CAS No.: 2226201-97-2
• Molecular Formula: C21H28ClN7O
• Molecular Weight: 429.95
• Purity: 99.94%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution
• Availability: In-stock

Source

Original product source