UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor ( D2R ) agonist with EC 50 <10 nM for β-arrestin-2 recruitment to D2 receptors. UNC9994 is simultaneously partial agonists of β-arrestin-2 translocation and antagonists of G i -regulated cAMP production. Antipsychotic Activity.
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