MRT-92

Overview

MRT-92 is a Smoothened ( Smo ) antagonist ( K i =0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor ( IC 50 =0.4 nM). MRT-92 can be used in the study of cerebellar glioma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > Smo | Products > Signaling Pathways > Hedgehog

Product Information

• Catalog No.: HY-117903A
• CAS No.: 1428315-82-5
• Molecular Formula: C33H34N4O5
• Molecular Weight: 566.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source