Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3 , 8 , 9 expression, enhances PI3K , AKT , SIRT1 , inhibits ROS , apoptosis , and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease.
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