ZD6021

Overview

ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with K i values of 0.12 nM for NK1 and 0.62 nM for NK2 . At a concentration of 100 nM, ZD6021 has a pK B value of 8.9 for human pulmonary artery NK1 receptors, and a pK B value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED 50 of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED 50 of 13 mg/kg.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Neurokinin Receptor

Product Information

• Catalog No.: HY-118378
• CAS No.: 255049-08-2
• Molecular Formula: C35H35Cl2N3O2S
• Molecular Weight: 632.64
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source