NS-6740

Overview

NS-6740 is a partial agonist of α7 nicotinic acetylcholine receptor ( α7 nAChR ) with an IC 50 of 3 nM. NS-6740 also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 alters the signaling pattern of α7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 induces the desensitized state of α7 nAChR . NS-6740 generates robust nAChR-mediated currents. NS-6740 reduces LPS ( HY-D1056 )-induced TNF-α release from microglia. NS-6740 can be used in the research of neuroinflammation and neuropathic pain.

Application

Products | Products > Disease Areas > Chronic Pain | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > nAChR | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-118646
• CAS No.: 753500-02-6
• Molecular Formula: C19H19F3N2O2
• Molecular Weight: 364.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source