N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone ( HY-17386 ), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone ( HY-17386 ).
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