Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK , ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca 2+ , thereby reducing neuronal apoptosis . Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Free Radical Scavengers | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > JNK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Apoptosis
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