AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.
Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > DNA/RNA Synthesis
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